Human growth hormone (HGH) is a vital component of the human endocrine system. It is secreted by the
pituitary gland, a small gland located at the base of the brain that produces
several hormones. In childhood and adolescence this hormone is necessary to
promote growth in height. In adulthood, its presence leads to a healthier body
composition and helps prevent the negative consequences of aging by:
·
Increasing
lean body mass
·
Decreasing
fat accumulation
·
Strengthening
bones
·
Protecting
organs (including skin) from the age-related decline
·
Promoting
rapid hair and nail growth
·
Improving
circulation
·
Improving
cholesterol levels
While most people believe
that the damaging effects of aging are inevitable, and it is
impossible to stop the rapid aging that seems to accelerate between the ages of 30
and 60, why should we assume this aging process is a “natural”
result of normal wear and tear?
There must be a reason why a
person who shows hardly any signs of
aging at 30 shows dramatic wear and
tear at 60!
According to the U.S. National Institutes of Health, the body’s natural production of HGH
starts to decline as early as age of 20, and continues to decline at a rate of 14% per decade.
The Role of HGH in
the Reversal of Aging
The effect of HGH on reversing the
damaging effects of aging was first brought to international attention of
medical science in a landmark 1990 New
England Journal of Medicine article, Effects
of Human Growth Hormone in Men Over 60 Years Old, which provided evidence
that the depletion of HGH (that starts occurring in people after they
pass the age of 30):
…is responsible for the decrease in lean body mass, the expansion of
adipose-tissue (fat) mass, and the thinning of skin that occurs in old age.
In a study the following year,
Iranmanesh et al found
that aging not only
reduces the natural (endogenous) HGH in the body, it also reduces the effectiveness of this HGH
through the number of HGH bursts during the day and the life span of the
endogenous HGH in the body:2
Linear regression analysis disclosed that age was a major negative
statistical determinant of GH secretory burst frequency (r = -0.80; P = 0.005)
and endogenous GH half-life.
HGH action is mediated by an HGH
receptor, which is expressed mainly in the liver. The progressive decline of
HGH levels lead to:
·
reduced lean body mass,
·
increased body fat – especially abdominal fat,
·
decreased bone mineral density, and
·
a worsened cardiovascular risk profile.
The net result is that a person
begins to both
look and feel older as HGH declines.
While HGH therapy does not affect
the root cause of aging (measured clinically by maximum lifespan), it does
slow, or even reverse many of the manifestations of aging, especially in older
people. Ideally, HGH therapy (or “boosting”) should start after a person reaches
the age of 30.
In adults, increased HGH levels have been shown to
reverse
the manifestations of aging by 5
to 20 years or more.
Benefits of Boosting
Your HGH Levels
HGH therapy has been shown to:
·
Reduce excess body fat (especially
abdominal fat, which has been shown to be a major risk factor in heart disease
and early death)
·
Increase muscle size (and strength
with an exercise routine)
·
Restore important internal organs
associated with hormone release
·
Reduce wrinkling of the skin and
improve skin elasticity
·
Increase bone density
·
Improve blood circulation through
increased production of bone marrow cells
·
Greatly reduces the risk of heart
disease and/or stroke
·
Strengthen the body’s immune
system and ability to fight off disease
·
Reverse or reduce memory loss
·
Reduce mental health problems,
especially depression
·
Improve overall quality of life
In a study of HGH therapy sponsored
by the U.S. Veterans Affairs Medical Center and Department of
Medicine at Stanford University, 202 patients that were treated with HGH reported
overall improvement
in their quality of life.
Patients reported improvement after HGH therapy in the following areas:
Area of improvement
|
Percent improvement
|
Healing
of other injuries
|
61
|
Wrinkle
disappearance
|
61
|
Emotional
stability
|
67
|
Exercise
tolerance
|
81
|
New
hair growth
|
38
|
Healing
capacity
|
71
|
Skin
thickness
|
68
|
Skin
elasticity
|
71
|
Back
flexibility
|
83
|
Muscle
size
|
81
|
Body
fat loss
|
82
|
Hot
flashes
|
58
|
Memory
|
62
|
Menstrual
cycle regulation
|
39
|
Duration
of penile erection
|
62
|
Resistance
to common illness
|
73
|
Skin
& hair care, skin texture
|
71
|
Strength
& body fat, muscle strength
|
88
|
Energy,
emotions & memory, energy level
|
84
|
Sexual
function, sexual potency/frequency
|
75
|
A 1991 study in Endocrine Reviews also increased interest on the aging
effects of declining HGH levels. The study reported that:3
Because HGH deficiency and normal aging are both associated with
decreases in protein synthesis and percentage of both lean body and bone mass,
along with increases in the percentage of body fat, it is possible that reduced
HGH levels account for one or more of the effects of aging. In several recent
studies, HGH therapy has resulted in improvements in nitrogen balance, an
increase in lean body mass, and a decrease in percent body fat.
Raising HGH Levels
Naturally
Starting at the age of 30, raising
the levels of HGH in our bodies can slow, or even reverse, the process of
aging. While there is no single therapy that is currently available that has
the impact that HGH therapy has, it is important
to note that to help your body produce
the maximum amount of HGH, a comprehensive approach that incorporates 4
key facets must be incorporated:
·
Training & exercise
·
Appropriate rest
· Proper nutrition and Supplementation
· Proper nutrition and Supplementation
Scientific Evidence
Supports HGH Therapy
Medical science had barely
scratched the surface of the anti-aging benefits of HGH therapy. Since then, several studies have provided scientific
proof of the benefits of HGH therapy in adults.
Evidence from clinical studies of the benefits of HGH therapy
HGH and exercise4,5
HGH therapy resulted in lower exercise oxygen consumption without a
drop-off in power output. The authors conclude that HGH therapy can improve
exercise performance.
and
HGH is directly involved in muscle adaptation to exercise because it
promotes muscle protein synthesis, muscle growth, and physical strength.
HGH and muscle strength
Subjects with low HGH levels had lower isometric knee extensor and knee
flexor strength than the general population. HGH therapy increased the mean
isometric knee extensor and flexor strengths. The increase in muscle strength was higher in
younger patients and in patients with lower initial muscle strength than expected.
HGH also increased and normalized isokinetic and isometric muscle strength.
HGH and protein synthesis
HGH therapy stimulated skeletal muscle protein synthesis. These
findings have important physiological implications for the role and the
mechanisms through which HGH therapy can promote protein anabolism, thus
improving protein synthesis and muscle growth.
HGH and protein metabolism
HGH therapy in individuals with HGH deficiency has been proven to
promote protein synthesis and reduce irreversible loss of protein through
oxidation. In this study, endurance-trained athletes were
given HGH therapy. Both during and after exercise, HGH therapy had a net
anabolic effect on whole body protein metabolism at rest and during and after
exercise, thereby improving protein synthesis and muscle growth.
HGH and injury
This review examined the positive performance-enhancing effect of HGH therapy
on both myofibrillar and connective tissue protein synthesis. HGH also plays a
role in the healing of connective tissue
injuries.
HGH and blood sugar levels
Supplemental HGH can improve body composition and serum lipid profile
(decreased body fat) without any significant impairment of glucose metabolism.
and
A study of elderly adults showed that HGH therapy can improve body
composition and serum lipid profile without any significant impairment of
glucose metabolism.
HGH and cardiovascular health
A deficiency in HGH
increases the risk of cardiovascular disease. HGH deficiency is also a factor
in adverse lipid profiles (increased fat), increased blood pressure, abnormal
body composition, increased body weight, increased blood thickening, and
increased inflammation markers, all leading to an increased risk of heart
attack and stroke.
HGH and immunity
HGH therapy improves the ability of the thymus gland to produce
disease-fighting T-cells, which are essential to the body’s immune system.
HGH and bone regeneration
Results confirm that HGH prevents
aging of the thymus gland…these data significantly extend earlier findings by
establishing that GH dramatically promotes the number of bone marrow cells.
HGH and movement
HGH replacement therapy normalized knee flexor strength and improved
knee extensor and handgrip strength.
HGH and body fat
HGH therapy significantly decreased the percentage of body fat and
increased the percentage of (lean) body weight, thus improving the ratio of
fat to lean weight, whereas the placebo treatment did not change any of
these measures.
HGH and obesity
HGH replacement in
abdominally obese premenopausal women increased bone strength, reduced
abdominal fat and inflammation, increased lean mass, and increased vitamin D
levels.
HGH and quality of life
A large proportion of adults with HGH deficiency have unequivocal
psychiatric morbidity. HGH therapy caused a rapid decrease in the symptoms of
depression and a subsequent increase in the patient’s perceived quality of
life.
and
Patients receiving HGH therapy experienced less perceived illness
than a placebo group. Significant psychological improvement was noted in the HGH-treated
patients' perception of their energy level and mood compared to the placebo
group.
HGH and mental health
HGH therapy had beneficial effects on the mental state in individuals
and appeared to have a beneficial effect on cardiovascular risk markers
associated with adverse mental health.
and
Subjects with HGH deficiency were administered HGH therapy. Before the
HGH therapy, the subjects had low self-esteem, a closed attitude towards social
relationships, a pessimistic attitude with a tendency towards depression, and a
strong sense of detachment from the outside world. After the HGH therapy, there
was an improvement in emotional control and well-being, accompanied by lowered
anxiety.
HGH and aging
HGH therapy in healthy, aged women and men increased lean body mass
and decreased fat mass. HGH therapy among the male subjects increased muscle
strength and VO(2)max (measurement of lung capacity).
and
Studies by Rudman et al. have shown that HGH therapy with elderly
subjects resulted in the reversal of many of the changes associated with HGH
deficiency, namely an increase in lean body mass and bone mineral density, as
well as a reduction in abdominal fat and plasma cholesterol.
and
Subsequent studies of HGH replacement in elderly adults have confirmed
Rudman's initial observations.
and
Blackman et al. investigated the effects of HGH with or without
testosterone supplements (in men) and estrogen supplements (in women). HGH therapy
increased lean body mass and aerobic capacity while reducing abdominal fat and
low-density lipoprotein cholesterol. HGH also showed the most potent anabolic
effects, and there was a positive interaction between GH and hormone replacement
with testosterone and estrogen.
Training
The first way to stimulate natural
HGH is through a training regimen. Training forces the body into a catabolic
state, requiring more protein synthesis and fat metabolism. Thus, training
requires more HGH from the body. However, the body’s production of HGH starts
to decline at the age of 30, and the ability for the body to build muscle and
burn fat decreases at the same time. Boosting natural HGH levels and utilizing
a training program will provide the optimal benefits for the body.
The effectiveness of HGH is vastly
improved
when used in conjunction with
training.
Benefits to the Body
with Boosted HGH Levels + Training
- New muscle is produced, and
muscle recovery or repair is improved.
- Lean body mass is increased
and maintained over the long-term
- Body fat is decreased and
maintained over the long-term
- Sleep is more productive,
with fewer wakenings and better REM-stage sleep.
- More energy is produced
- Sexual performance is
enhanced
- Bone strength is increased
- Important internal organs,
such as the heart and kidneys, show improved function
With the proper training regimen,
HGH can be manipulated to achieve the maximum benefit. The common mistake most
people make when they start a training regimen is that “more is better” so they
think the only way they can achieve overall fitness are long cardio workouts
lasting 45 minutes or more.
The truth is that a proper 20-minute
workout
is the best way to achieve your
optimal fitness level
This type of workout will optimally
engage your muscles and maximize your HGH benefits.
Choose a type of anaerobic exercise
Anaerobic exercise is defined as a short-lasting,
high-intensity activity, where your body's demand for oxygen exceeds the oxygen
supply available. This type of
exercise relies on energy sources that are stored in the muscles.
The best anaerobic exercises that
utilize the larger muscles in the body are:
·
sprinting,
·
stair climbing,
·
running on an incline,
·
biking,
·
using an elliptical exerciser or a
·
rowing machine.
Note:
Before you start the training session, it is always important to warm-up!
Exercise Routine
v Your
routine will be done in 8 sets
v The
first part of each set lasts 30 seconds
During this time you
will exercise as fast/hard as possible. You want to feel exhausted at the end
of the 30 seconds.
v After
30 seconds, slow down your pace significantly and continue for 90 seconds
v Repeat
7 more times
Three Basic Steps of
Training
Now that you have your training
regimen you need to follow 3easy rules.
Step 1
When you first begin a training regimen you
need to pace yourself.
You shouldn’t expect that you will be running a marathon next Sunday! This is
especially true if you have not been exercising anything more than the remote
control on your TV up to now! Also, anyone over the age of 40 should ease into
training. Don’t worry, after a couple of sessions you’ll start to feel the improvement
in your muscles and in your endurance.
Step 2
Train every 3rd day. Your body needs to recover,
and after training most people need 2 days of recovery to prevent injury or
exhaustion.
Step 3
Training requires additional nutrition so that
your body can naturally build up your HGH levels, some of the most important
being amino acids.
Amino acids help the body produce
more HGH,
thus combat the age-related
decline of HGH levels
Rest
In recent years every survey on the
sleep patterns of Americans comes to one conclusion: we don’t get enough sleep!
Sleep deprivation has so many
negative effects on our health - both mentally and physically-and on our
overall quality of life. Most of the body’s HGH is produced during sleep, mainly
in the REM (rapid eye movement) cycles of sleep. Sleep deprivation disrupts or
prevents these REM cycles.
The US Centers for Disease Control
and Prevention recommend 8-10 hours of sleep per
day. But this is not always possible – especially with today’s busy schedules - just do the best you can. An established sleeping
pattern can also increase REM cycles, thus producing more HGH.
It is recommended that you should try to go to bed at or around the same
time and wake up at or around the same time every day.
Nutrition
GenF20 is a nutritional supplement that will both maximize your training outcomes and delay and/or prevent age-related
degeneration.
GenF20 serves as an “HGH releaser”, by
stimulating the pituitary gland in
the body to produce more HGH
The end result is that you will
receive all the benefits of increased natural HGH and the anti-aging and health
benefits that come with it.
Why GenF20,
why not just “get” some HGH?
GenF20 works by boosting natural HGH levels. While HGH can be received via injection and is considered more effective, injectable HGH is very expensive, comes with many adverse side effects,and usually requires a prescription.
GenF20 works by boosting natural HGH levels. While HGH can be received via injection and is considered more effective, injectable HGH is very expensive, comes with many adverse side effects,and usually requires a prescription.
In addition to the amino acids, GenF20 contains other beneficial nutrients
for prolonging youth and overall improved health and fitness.
GenF20 Ingredients
Amino
Acids
|
||
L-Arginine
|
Ø Has
been proven to boost natural HGH levels by approximately 300%
Ø Aids
in the repair of cartilage, thus protecting joints
|
|
L-Glutamine
|
Ø Acts
directly on the pituitary gland to boost HGH production
Ø Improves
alertness
Ø Reduces
stress
Ø Aids
in the maintenance and regulation of body tissues
|
|
L-Glycine
|
Ø Acts
on the pituitary gland to create a steady increase in HGH production
|
|
L-Lysine
|
Ø When
used in combination with L-Arginine, the level of HGH production increases
10X compared to the use of L-Arginine alone
|
|
L-Ornithine
|
Ø In
conjunction with L-Arginine, L-Ornithine can boost HGH to optimal (pre-aging)
levels
|
|
L-Tyrosine
|
Ø Works
on the pituitary gland to raise HGH production
Ø Lessens
fatigue
Ø Enhances
mental health
Ø Reduces
signs of depression
Ø Regulates
and enhances the body’s metabolic processes
|
|
L-Valine
|
Ø Essential
for muscle metabolism and growth
|
|
Other
Nutrients
|
||
Astragalus root
|
Used in traditional Chinese
medicine
Ø Combats
the slower metabolism that comes with age
Ø Naturally
raises metabolism, thus reducing fat and increasing lean body mass
|
|
Deer velvet antler
|
Ø Important
source of hormones, some of which work to directly stimulate HGH production
Ø Helps
in the repair of cartilage, thus protecting joints
|
|
Colostrum
|
Ø Contains
insulin-like growth factors, and important component of HGH production
Ø Helps
to maintain a healthy immune system
Ø Reduces
recovery time after workout
Ø Promotes
fasting healing times for injuries
Ø Improves
bone strength
|
|
GABA
|
Functions as a neurotransmitter
Ø Improves
mental processes
Ø Facilitates
HGH production
Ø Reduces
confusion
Ø Maintains
nervous system
|
|
Pituitary powder
|
Ø Works
on pituitary gland to boost HGH production
Ø Improves
muscle tone
|
|
Phosphatidyl choline
|
Ø Plays
no role in HGH production
Ø Helps
the body absorb the nutrients in GenF20
|
|
GTF chromium
|
Ø Maintains
blood sugar levels, facilitating HGH production
|
|
The stimulating effect the
ingredients in GenF20 have on natural HGH production in combo with diet and exercise directly
counteracts the inevitable age-related decline in HGH levels, allowing you to
lead an active, healthy, and more youthful life.
References
1.
Rudman D, Feller AG, Nagraj HS, et al. Effect of
human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1–6.
2.
Iranmanesh A, Lizarralde G, Velduis JD. Age and
relative adiposity are specific negative determinants of the frequency and
amplitude of growth hormone secretory bursts and the half-life of endogenous GH
in healthy men. J Clin Endocrinol
Metab. 1991;73:1081–8.
3.
Corpas E, Harman SM, Blackman MR. Human growth hormone
and human aging. Endocrine
Rev. 1993 Feb;14(1):20-39.
4.
Irving BA, Patrie JT, Anderson SM, et al. The
effects of time following acute growth hormone administration on metabolic and
power output measures during acute exercise. J Clin Endocrinol Metab. 2004;89:4298–305.
5.
Fryburg DA, Gelfand RA, Barrett EJ. Growth
hormone acutely stimulates forearm muscle protein synthesis in normal humans. Am J Physiol. 1991;260:499–504.
6.
Johannsson G, Grimby G, Sunnerhagen KS, et al.
Two years of growth hormone (GH) treatment increases isometric and isokinetic
muscle strength in GH-deficient adults. J Clin Endocrinol Metab. 1997;82:2877–84.
7.
Doessing M, Kjaer M. Growth hormone and
connective tissue in exercise. Scand
J Med Sci Sports. 2005;15:202–10.
8.
Healy ML, Gibney J, Russell-Jones DL, et al.
High dose growth hormone exerts an anabolic effect at rest and during exercise
in endurance-trained athletes. J Clin Endocrinol
Metab. 2003;11:5221–6.
9. Franco
CC, Johannsson G, Bengtsson B, et al. Baseline
characteristics and effects of growth hormone therapy over two years in younger
and elderly adults with adult onset GH deficiency. J Clin Endocrinol Metab. 2006, Vol. 91,
No. 11. pp. 4408-4414.
10. Verhelst
J, Ab R. Cardiovascular
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11. Morrhaye
G, Kermani H, Legros JJ, et al. Impact of growth hormone (GH) deficiency and GH replacement upon
thymus function in adult patients. PLoS One. 2009 May 22; Vol. 4, issue 5:e5668.
12. French
RA, Broussard SR, Meier WA, et al. Age-associated
loss of bone marrow hematopoietic cells is reversed by GH and accompanies
thymic reconstitution. Endocrinology.
2002 Feb; Vol. 143, issue 2, pp. 690-9.
13.
Crist
DM, Peake GT, Egan PA, et al. Body composition response to exogenous GH during
training in highly conditioned adults. J
Appl Physiol. 1988;65:579–84.
14.
Bredella
MA, Gerwek AV, Barber LA, et al. Effects of growth
hormone administration for 6 months on bone turnover and bone marrow fat
in obese premenopausal women. Bone.
2014 May;62:29-35.
15.
Mahajan
T, Crown A, Checkley S, et al. Atypical depression in growth hormone deficient
adults, and the beneficial effects of growth hormone treatment on depression
and quality of life. Eur J
Endocrinol. 2004;151:325–
16.
McGauley
GA. Quality of life assessment before and after growth hormone treatment in
adults with growth hormone deficiency. Acta
Paediatr Scand. 1989;356:70–2.
17.
Graham
MR, Baker JS, Evans P, et al. Recombinant human growth hormone in abstinent
androgenic-anabolic steroid use: Psychological, endocrine, and trophic factor
effects. Curr Neurovasc Res. 2007a;4:9–18.
18.
Riva G,
Molinari E. Body image and social attitude in growth-hormone-deficient
adults. Percept Mot Skills. 1995;80:1083–8.
19.
Blackman
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